PNC-27 (10mg)

Product Description

Follistatin (FLGR242), is a novel fragmented, modified version of Follistatin-344 (FST-344) that does not bind to the protein activin. Activin is responsible for the negative effects of myostatin inhibition such as unwanted cellular growth in laboratory models. It also contains a patented albumin binder.

Follistatin protein (FST) fused with an albumin-binding construct that uses a hydrophilic glycine-serine linker to achieve high-affinity binding to serum albumin (<20 nM Kd). This recombinant technology allows researchers to study follistatin-albumin interactions and protein trafficking in experimental systems.

Research applications include muscle mass development studies, activin neutralization assays, and TGF-β superfamily pathway modulation with albumin binding dynamics. The construct maintains biological activity while enabling investigation of albumin as a carrier protein.

US GMP-manufactured with third-party verification and comprehensive COAs for reproducible research outcomes.

Peptide Information

Lyophilized Peptides:

These peptides are freeze-dried, a process that not only extends shelf life but also preserves the purity and integrity of the peptides during storage. We do not use any fillers in this process.

Product Usage:

This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only.  This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug.

Product Description

Follistatin (FLGR242), is a novel fragmented, modified version of Follistatin-344 (FST-344) that does not bind to the protein activin. Activin is responsible for the negative effects of myostatin inhibition such as unwanted cellular growth in laboratory models. It also contains a patented albumin binder.

Follistatin protein (FST) fused with an albumin-binding construct that uses a hydrophilic glycine-serine linker to achieve high-affinity binding to serum albumin (<20 nM Kd). This recombinant technology allows researchers to study follistatin-albumin interactions and protein trafficking in experimental systems.

Research applications include muscle mass development studies, activin neutralization assays, and TGF-β superfamily pathway modulation with albumin binding dynamics. The construct maintains biological activity while enabling investigation of albumin as a carrier protein.

US GMP-manufactured with third-party verification and comprehensive COAs for reproducible research outcomes.

Peptide Information

Lyophilized Peptides:

These peptides are freeze-dried, a process that not only extends shelf life but also preserves the purity and integrity of the peptides during storage. We do not use any fillers in this process.

Product Usage:

This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only.  This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug.

Product Description

alphaKlothoLR is a patented, long-release version of the recombinant Klotho protein, which contains specific amino acid sequences, linkers, and an albumin binding group that allows for a sustained delivery of Klotho with cellular activity up to 19 days.

This research-grade construct combines α-Klotho protein with a proprietary 29-amino acid albumin binding peptide (GGSGGSGGSGGRLIEDICLPRWGCLWEDD). The modification enables strong albumin binding affinity (<20 nM) while maintaining native FGF23 binding activity (15-30 nM).

Produced through recombinant expression with rigorous third-party testing. Each batch includes HPLC and LC-MS verification to confirm molecular identity and purity standards. Complete analytical documentation supports laboratory applications investigating protein-albumin interactions, FGF23 signaling pathways, and albumin binding mechanisms.

For in vitro research use only.

Klotho Protein Information

Lyophilized Peptides:

These peptides are freeze-dried, a process that not only extends shelf life but also preserves the purity and integrity of the peptides during storage. We do not use any fillers in this process.

Product Usage:

This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only.  This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug.

Product Description

BioBAM-15 contains BAM15, a small-molecule mitochondrial protonophore used as a research tool to uncouple oxidative phosphorylation. It ferries protons across the inner mitochondrial membrane, dissipating membrane potential (Δψm) and weakening the proton motive force that normally drives ATP synthase.

BAM15 was discovered in screens explicitly looking for uncouplers with fewer confounds. Compared with FCCP at similar uncoupling potency, BAM15 was reported to avoid plasma membrane depolarization, show lower cytotoxicity, and stimulate respiration across a broader effective concentration range, which can make titrations and mechanistic readouts less “knife-edge.”

That profile is why BAM15 shows up in mitochondrial function experiments as an alternative to classical uncouplers, especially when investigators want to separate mitochondrial uncoupling from off-target electrophysiology at the cell surface.

Specifications